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Identification of genes involved in regulation and execution of programmed cell death in Aradidopsis thaliana: a funcional genomics approach

English title Identification of genes involved in regulation and execution of programmed cell death in Aradidopsis thaliana: a funcional genomics approach
Applicant Apel Klaus
Number 110774
Funding scheme SCOPES
Research institution Departement Umweltsystemwissenschaften ETH Zürich
Institution of higher education ETH Zurich - ETHZ
Main discipline Botany
Start/End 01.11.2005 - 31.10.2008
Approved amount 70'960.00
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All Disciplines (3)

Discipline
Botany
Molecular Biology
Genetics

Keywords (1)

PCD

Lay Summary (English)

Lead
Lay summary
Programmed cell death (PCD) is a genetically controlled suicidal process in which cells self-destruct upon certain cell death stimuli, selectively removing in this way unwanted cells. This process is an essential part of plant development as well as of many plant responses to abiotic stress and pathogens. Examples of PCD can be found during development of the embryo, maturation of tracheal elements and epidermal trichomes, leaf senescence and the hypersensitive response (HR) - a defense against pathogens. While the process is well studied in animals, little is known about the mechanisms and genes involved in plant PCD.

The main aim of the proposed project is to unravel the mechanisms behind the plant PCD by discovering genes involved in the regulation and execution of PCD in the model species Arabidopsis thaliana. To realize that goal two experimental approaches will be used: (1) forward genetics, in which we will screen for mutations in genes that render plants altered in PCD responses, and (2) expression profiling of PCD coupled with reverse genetics, in which by extensive microarray analysis we will identify genes that are transcriptionally regulated during PCD and those genes will be functionally studied by the knock out technology or by generating plants with altered expression of the genes.

The proposed project will create vibrant research links between the two partners and improve significantly the research conditions of the Bulgarian partner, thus making the East European partner more competitive on the national and international level.
Direct link to Lay Summary Last update: 21.02.2013

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