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EEG spectral and source analysis in neurogenic pain and Parkinson's disease

English title EEG spectral and source analysis in neurogenic pain and Parkinson's disease
Applicant Sarnthein Johannes
Number 110028
Funding scheme Project funding (Div. I-III)
Research institution Neurologische Klinik Universitätsspital Zürich
Institution of higher education University of Zurich - ZH
Main discipline Neurophysiology and Brain Research
Start/End 01.02.2006 - 31.12.2007
Approved amount 178'508.00
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Keywords (8)

Human; EEG; LFP; theta; LORETA; thalamus; stereotaxy; Parkinson

Lay Summary (English)

Lead
Lay summary
The research of the Laboratory for Functional Neurosurgery has over thelast years characterized a common physiopathological mechanism for severalfunctional disorders, including central neurogenic pain and Parkinson’sdisease. Intra-operative recordings of cellular activities show rhythmicbursting activities which could be identified as low threshold calciumspike bursts (LTS). Taking into account (1) the presence of LTS, (2) thetherapeutic possibilities of surgery against both diseases, (3) the denseand reciprocal interconnection between thalamus and cortex, and (4) aslowing of magnetoephalographic spectra, a common physiopathology wasproposed, which involves the thalamocortical reentry loop, and themechanism was named thalamocortical dysrhythmia.
The present project plans to record the clinical state and scalp EEG froma larger group of patients with neurogenic pain and Parkinson’s diseasebefore surgery and 3 and 12 months after surgery as clinical improvementstabilizes. With advanced techniques of spectral analysis and EEG sourcelocalization we aim (1) to describe the differences between patient andcontrol EEG parameters preoperatively, and (2) to follow the evolution ofEEG parameters after the surgical intervention. In this way we expect torefine our understanding of the physiopathology of neurogenic pain andParkinson’s disease and to develop non-invasive scalp EEG as diagnostictool for clinical practice. Once a faithful relationship between EEGparameters and clinical outcome is established, EEG could attain apredictive value for the efficiency of neurosurgical interventions inindividual patients. Furthermore, EEG could then also become useful forthe diagnosis and non-invasive treatment of less severe forms of thediseases.
The significance of the research presented here lies in the large numberof patients with a chronic, severe and therapy-resistant form ofneurogenic pain or Parkinson’s disease, increasing with aging of thepopulation in Switzerland. These patients will directly benefit from animproved understanding of their physiopathology as well as from a newdiagnostic tool supporting all therapeutic options.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Automatic detection of high frequency oscillations during epilepsy surgery predicts seizure outcome.
Fedele Tommaso, van 't Klooster Maryse, Burnos Sergey, Zweiphenning Willemiek, van Klink Nicole, Leijten Frans, Zijlmans Maeike, Sarnthein Johannes (2016), Automatic detection of high frequency oscillations during epilepsy surgery predicts seizure outcome., in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiol, 127(9), 3066-74.
Correlations between EEG and clinical outcome in chronic neuropathic pain: Surgical effects and treatment resistance
Michels Lars, Moazami-Goudarzi Morteza, Jeanmonod Daniel (2011), Correlations between EEG and clinical outcome in chronic neuropathic pain: Surgical effects and treatment resistance, in Brain Imaging and Behavior, 5(4), 329-348.
EEG alpha distinguishes between cuneal and precuneal activation in working memory
Michels Lars, Moazami-Goudarzi Morteza, Jeanmonod Daniel, Sarnthein Johannes (2008), EEG alpha distinguishes between cuneal and precuneal activation in working memory, in NEUROIMAGE, 40(3), 1296-1310.
Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients
Moazami-Goudarzi Morteza, Sarnthein Johannes, Michels Lars, Moukhtieva Renata, Jeanmonod Daniel (2008), Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients, in NEUROIMAGE, 41(3), 985-997.
Test-retest reliability of EEG spectra during a working memory task
Naepflin Markus, Wildi Marc, Sarnthein Johannes (2008), Test-retest reliability of EEG spectra during a working memory task, in NEUROIMAGE, 43(4), 687-693.
Test-retest reliability of resting EEG spectra validates a statistical signature of persons
Näpflin Markus, Wildi Marc, Sarnthein Johannes M. (2007), Test-retest reliability of resting EEG spectra validates a statistical signature of persons, in Clinical Neurophysiology, 118(11), 2519-2524.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Society for Neuroscience Annual Meeting Talk given at a conference One theta and two alpha generators in working memory 07.11.2007 San Diego, United States of America Sarnthein Johannes; Michels Lars;
Minisymposium: Thalamocortical Interactions in Health and Disease: From Ion Channels to Large-scale Networks Individual talk High Thalamocortical Theta Coherence in Patients with Parkinson's Disease 05.11.2007 San Diego, United States of America Sarnthein Johannes;
Society for Neuroscience Annual Meeting Talk given at a conference Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients 03.11.2007 San Diego, United States of America Sarnthein Johannes;


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