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Development and analysis of cell-based biodegradable scaffolds to repair myocardial defect

English title Development and analysis of cell-based biodegradable scaffolds to repair myocardial defect
Applicant Tevaearai Hendrik
Number 108417
Funding scheme Project funding (Div. I-III)
Research institution Department for BioMedical Research Universität Bern
Institution of higher education University of Berne - BE
Main discipline Structural Research
Start/End 01.05.2005 - 30.04.2008
Approved amount 197'000.00
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Keywords (5)

heart failure; cell therapy; tissue engineering; myoblasts; cell culture

Lay Summary (English)

Lead
Lay summary
Stemm cells are of special interest due to the possibility of implanting cells of autologous origin. However, even though initial phase I clinical studies already demonstrated the potential major benefit of transplanting these cells in myocardium of patients with severe HF, several key questions remain to be studied. In addition, developing patches based on the conjunction of myoblasts and a biodegradable scaffold allows the formation of myotubes before the implantation. Consequently, not only the patch implantation process may significantly increase the concentration of cells as compared to direct injection, but also these cells may already be partially differentiated or even conditioned before the implantation. Subsequently these advantages may lead to a functional benefit. Developing a contracting bioartificial tissue may therefore find a possible interest in patients with regional contractile alteration (post-myocardial infarct), in patients with ischemic or non-ischemic global ventricular dysfunction as well as in patients with a congenital myocardial defect.We aim to develop bio-artificial contractile constructs and evaluate their potential functional benefit when implanted at the surface of a hearts with local contractile defect such as those observed after a myocardial infarction. Our specific aims are:1.To develop and evaluate new potential scaffolds for in-vitro stemm cell seeding,2.To analyze the contractile properties of those patches in vitro,3.To investigate the functional benefit of implanting those patches on failing hearts,4.To study the potential recovery of native cardiomyocytes after patch implantation,5.To study the long-term evolution of those biodegradable patches in vivo.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
65044 Adenoviral-mediated gene modulation of the beta-adrenergic signaling reverse remodeling in unloaded failing hearts 01.10.2001 Project funding (Div. I-III)

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