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Insufficient neovascularization in patients with peripheral arterial disease: Impaired up-regulation or failed synchronization of angiogenesis inducers?

English title Insufficient neovascularization in patients with peripheral arterial disease: Impaired up-regulation or failed synchronization of angiogenesis inducers?
Applicant Baumgartner Iris
Number 108309
Funding scheme Project funding (Div. I-III)
Research institution Department for BioMedical Research Universität Bern
Institution of higher education University of Berne - BE
Main discipline Clinical Cardiovascular Research
Start/End 01.05.2005 - 30.04.2007
Approved amount 151'300.00
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All Disciplines (2)

Discipline
Clinical Cardiovascular Research
Molecular Biology

Keywords (6)

angiogenesis; angiogenic growth factors; anti-angiogenesis; diabetes; mellitus; endothelial cell

Lay Summary (English)

Lead
Lay summary
Peripheral arterial disease (PAD) of the lower extremities is a common form of atherosclerotic disease and a leading cause of morbidity and mortality.Diabetes is a major cardiovascular risk factor for PAD associated with 10-fold increased amputation.The concept of “therapeutic angiogenesis” based on the use of specific growth factors to stimulate neovascularization to restore adequate perfusion to the ischemic areas, has provided promising perspectives for the treatment of ischemic diseases including PAD.A deep characterization of the endogenous expression profile of the angiogenic factors and the pathogenetic changes occurring at the cellular and molecular level of PAD is mandatory to develop safe and efficient therapeutic strategies. In the past years we have focused on the investigation those aspects using a multidisciplinary approach based on gene/protein expression as well as immunohistochemical profiling of skeletal muscle tissue of patients with PAD.To this ends we have collected skeletal muscle tissue from amputated limbs from diabetic and non diabetic patients and studied the ultrastructure of the microvasculature. In addition we have described the expression of different factors with angiogenic and anti-angiogenic functions.
Direct link to Lay Summary Last update: 21.02.2013

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