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Functional genomics of sex determination and ovarian development in mice

English title Functional genomics of sex determination and ovarian development in mice
Applicant Nef Serge
Number 108245
Funding scheme Project funding (Div. I-III)
Research institution Dépt Microbiologie et Médecine Moléculaire Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Embryology, Developmental Biology
Start/End 01.04.2005 - 31.03.2008
Approved amount 335'000.00
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Keywords (5)

sex determination; ovary; testis; gonads; mice

Lay Summary (English)

Lay summary
Our research effort is geared toward a better understanding of sex determination and gonadal function, by providing insights into the molecular and signaling pathways operating in the differentiating gonads but also during spermatogenesis or oogenesis. We are currently investigating the involvement of Dicer and microRNAs, a novel class of post-transcriptional regulators, in gonadal development as well as ovarian and testicular functions. So far, our results indicate that miRNAs are required for normal spermatogenesis both in the supporting and germ cell lineages. These exciting phenotypes are currently analyzed into more details. Overall, this study provides the first evidence that Dicer, and presumably microRNAs, is essential for spermatogenesis, and and may further our understanding of male infertility in humans.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
135227 Investigating the roles of insulin/IGF signaling in mediating adrenal development and sex determination in mice 01.04.2011 Project funding (Div. I-III)
119862 Critical roles for microRNAs in mouse spermatogenesis 01.04.2008 Project funding (Div. I-III)