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Evaluation eines neu entwickelten Basismoduls zur Therapie von Neurokognition und sozialer Kognition in der Behandlung und Rehabilitation schizophren Erkrankter

English title Evaluation of a newly developed basis module for treating neuro- and social cognition in schizophrenia patients
Applicant Roder Volker
Number 108133
Funding scheme Project funding (Div. I-III)
Research institution Universitätsklinik für Psychiatrie
Institution of higher education University of Berne - BE
Main discipline Neurology, Psychiatry
Start/End 01.07.2005 - 31.05.2010
Approved amount 227'000.00
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Keywords (7)

schizophrenia; behaviour therapy; rehabilitation; neurocognition; social cognition; cognition; functional outcome

Lay Summary (English)

Lead
Lay summary
Objectives: Neuro-cognition and social cognition might have a decisive influence and prognostic value for poor functional recovery of most schizophrenia patients. The NIMH MATRICS initiative established a consensus about different neuro-cognitive and social cognitive domains that are relevant for the assessment and treatment of schizophrenia. Against this background we developed a cognitive-behavioural group therapy program (INT: Integrated Neuro-cognitive Therapy) covering these treatment domains. INT intends to restitute and compensate neuro-cognitive and social cognitive (dys-) functions. This "bottom up" and "top down" approach puts a strong focus on the patients' daily life context to promote transfer and generalization. INT additionally facilitates intrinsic motivation, resources and group processes.Methods: INT is currently evaluated in an ongoing international randomized multi-cite study in Switzerland, Germany and Austria, which is supported for 5 years by the Swiss National Science Foundation. INT is compared with treatment as usual (TAU). Patients receive 30 therapy sessions twice a week, lasting 90 minutes each. Assessments comprise proximal and distal measures. They are applied before and after therapy and at a 1-year follow-up. Up to now 145 outpatients participate in the study.Results: INT patients obtain medium effect sizes in neuro-cognitive and social cognitive variables, insight, negative symptoms and social functioning. Some effect sizes still augment at follow-up. Finally, a low drop-out rate of 9% of the INT patients during the study represents a high acceptance by the patients.Conclusion: As further development of the cognitive part of IPT (Integrated Psychological Therapy) INT seems to be a significant group therapeutic intervention that fits for younger not severely chronically ill patients to help them to (re-)gain functional recovery. INT should be administered over longer periods of time (at least 6 to 12 months). At the study end in May 2010 we expect data sets of about 190 patients.
Direct link to Lay Summary Last update: 21.02.2013

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