Project

Back to overview

Protein folding in membranes and multiple drug resistance

English title Protein folding in membranes and multiple drug resistance
Applicant Seelig Joachim
Number 107793
Funding scheme Project funding (Div. I-III)
Research institution Abteilung Biophysikalische Chemie Biozentrum der Universität Basel
Institution of higher education University of Basel - BS
Main discipline Biophysics
Start/End 01.04.2005 - 31.03.2010
Approved amount 919'000.00
Show all

Keywords (7)

protein folding; multidrug resistance; membranes; titration calorimetry; magnetic resonance; cytocensor; bonus-of-excellence

Lay Summary (English)

Lead
Lay summary
The group of J. Seelig is concerned with mainly two topics: (1) the membrane-induced random-coil V b-structure transition as observed for Alzheimer peptide Ab and (2) the action mechanism of cell penetrating peptides (CPPs) such as TAT-PTD, different polyarginines (R5-R9), and dioleoylmelittin (DOM). The group of Anna Seelig is interested in the passive and active transport of drugs across the biological membrane, in particular the blood brain barrier (BBB). The main focus is on the quantitative understanding of multidrug resistance produced by the membrane-spanning P-glycoprotein (Pgp).
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
129701 Cell-penetrating peptides, protein folding and multi-drug resistance 01.06.2010 Project funding (Div. I-III)
58800 Protein folding in membranes and diagnostic in vivo magnetic resonance 01.04.2000 Project funding (Div. I-III)

-