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Nahtlose, laser basierte hochfluss Anastomose von Hirnarterien, ohne temporäre Abklemmung

English title Sutureless laser based highflow anastomosis for cerebral arteries, without temporary occlusion
Applicant Reinert Michael
Number 107611
Funding scheme Project funding (Div. I-III)
Research institution Universitätsklinik für Neurochirurgie Inselspital Bern
Institution of higher education University of Berne - BE
Main discipline Neurophysiology and Brain Research
Start/End 01.05.2005 - 30.04.2009
Approved amount 227'000.00
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All Disciplines (2)

Neurophysiology and Brain Research

Keywords (6)

cerebral revascularization; vessel welding; bio-glue; diode laser; erbium-yag laser; excimer laser

Lay Summary (English)

Lay summary
Cerebral revascularization using a non-occlusive technique, meaning without any temporary occlusion, is a neurosurgical procedure which has the potential to decrease morbidity and mortality in patients suffering severe cerebral hemodynamic compromise. This can be due to an occlusion of a brain supplying artery, a compromise or pathology in intracerebral arteries or in patients suffering of a skull base tumor. In these patients the best medical care is not effective and interventional neuroradiological procedures are either not possible or the risks are too high. If such a situation is diagnosed a cerebral revascularization should be considered.
Standard Extracranial-Intracranial Bypass procedure, which is a lowflow Bypass technique, can be sufficient in some cases to provide enough blood perfusion to brain areas and to restore energy homeostasis, such as Moyamoya disease. The recent clinical introduction of a technique using an excimer laser without temporary occlusion has improved the technical possibilities where a therapeutic opportunity can now be offered to patients where there has previously been none. Yet this technique still involves a surgical suture in the depth of a craniotomy and thus poses clinical difficulties and risks for patients. A further improvement and facilitation of the technique is our most envious aim and to enlarge the spectrum for different arterial blood vessel calibres as well as veins.
The risk for patients shall thus be reduced and the treatment possibilities increased. The idea is to use compact laser sources, different catheters and mainly to develop a sutureless fusion between the blood vessels with biological glue. An important improvement will be to relieve the anastomosis of the angle dependency for the perforation procedure.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
133083 Sutureless Endoluminal and Transmural Microvascular Laser-Anastomosis for Minimally Invasive Microsurgical Procedures in Bypass and Revascularization Surgery 01.04.2011 Project funding (Div. I-III)