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Intracellular signaling pathways during lymphocyte trafficking

English title Intracellular signaling pathways during lymphocyte trafficking
Applicant Stein Jens Volker
Number 107510
Funding scheme Project funding (Div. I-III)
Research institution Theodor Kocher Institut Medizinische Fakultät Universität Bern
Institution of higher education University of Berne - BE
Main discipline Immunology, Immunopathology
Start/End 01.04.2005 - 31.03.2008
Approved amount 343'811.00
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All Disciplines (4)

Discipline
Immunology, Immunopathology
Biochemistry
Molecular Biology
Cellular Biology, Cytology

Keywords (7)

limphocyte trafficking; G-protein coupled receptors; chemokines; migration; small GTPases; adhesion; intravital microscopy

Lay Summary (English)

Lead
Lay summary
Lymphocytes continuously migrate through the body in search of foreign Antigen (Ag). This migration protects the organism from microbial infections, but can occasionally also lead to autoimmune disease. It is therefore important to understand the molecular mechanisms which control lymphocyte trafficking.Chemokines are small secreted polypeptides which control lymphocyte migration by attracting these cells into specific organs, such as lymph nodes and spleen, or to inflamed tissue. Chemokines bind specific receptors on the lymphocytes, which in turn trigger a wide array of incompletely understood signaling pathways. The project funded by the SNF and carried out in this laboratory aims to better characterize the molecular players which are activated by chemokines. This novel insight should allow to better model immune responses in health and disease.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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Associated projects

Number Title Start Funding scheme
120640 In vivo analysis of intracellular signaling pathways during lymphocyte trafficking and activation 01.04.2008 Project funding (Div. I-III)

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