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SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population

English title SAPALDIA COHORT STUDY: Impact of air pollution on the cardiovascular and respiratory system in the Swiss population
Applicant Ackermann-Liebrich Ursula
Number 104284
Funding scheme Project funding (special)
Research institution Institut für Sozial- und Präventivmedizin Universität Basel Swiss TPH
Institution of higher education University of Basel - BS
Main discipline Respiratory Diseases
Start/End 01.04.2004 - 30.11.2007
Approved amount 534'564.00
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All Disciplines (4)

Discipline
Respiratory Diseases
Methods of Epidemiology and Preventive Medicine
Clinical Cardiovascular Research
Cardiovascular Diseases

Keywords (6)

cohort; heart rate variability; cardiovascular risk factors; lung function tests; bronchial responsiveness; epidemiology

Lay Summary (English)

Lead
Lay summary
Background
In 1991, the Swiss Study on Air Pollution and Lung Diseases in Adults(SAPALDIA) examined 9'651 subjects in eight different areas ofSwitzerland. The areas were selected to represent a broad range ofenvironmental conditions. Eleven years later (2001-3), 8'047 (83%) of theoriginal population participated in the follow-up. In the follow-up, theextensive health examination was repeated and expanded. A new component tothe study was the measurement of heart rate variability, as a marker forcardiovascular health, by Holter recordings in a random sample of 1'923subjects aged over 50.

Aims
a1) To determine heart rate variability in men and women in the SAPALDIAcohort
a2) To determine the prevalence of cardiovascular risk factors in men andwomen in the SAPALDIA cohort and the subpopulation with Holterrecordings
a3) To determine the influence of cardiovascular risk factors (bloodpressure, BMI, smoking, physical activity etc), biomarkers forcardiovascular health (glucose, glycosylated haemoglobin, creatinin, uricacid and lipids) and current health status on the results from the Holterrecordings; particularly heart rate variability
a4) To determine associations between heart rate variability andcardiovascular risk factors, lung function and bronchialresponsiveness
b) To investigate the association between heart rate variability andlong-term exposure to air pollutants

Methods
Heart rate variability will be described with and without adjustment forother factors including standard demographic variables and knowncardiovascular risk factors (smoking, cholesterol, BMI etc). Inparticular, the influence of air pollutant exposure levels on heart ratevariability will be investigated and we will look for potentialinteractions between blood markers and other important cardiovascular riskfactors. We will determine relations between measures of heart ratevariability and cardiovascular risk factors with lung function and airwayresponsiveness and with change in lung function and airway responsivenessover the 11 year follow-up.

Importance of the project
Few cohort studies have been set up to examine the effects of long-termexposure to air pollutants on health in adults. The SAPALDIA Cohort Studywill enable us to evaluate the effects of long-term exposure to airpollution on heart rate variability using measurements of individualexposure. We will also have the possibility to explore the interactionbetween heart rate variability and lung function decline over an 11-yearperiod.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
65896 The SAPALDIA II Cohort Study:Impact of environmental and personalrisk factors on the occurrence, course, remission and progressionof respiratory diseases in the Swiss population. 01.10.2001 Project funding (special)
134276 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2011 Cohort Studies Large

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