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SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis

English title SAPALDIA COHORT STUDY: Impact of environmental and personal risk factors on the occurrence, course, remission and progression of respiratory disease in the swiss population-data analysis
Applicant Rochat Thierry
Number 104283
Funding scheme Project funding (special)
Research institution Service de Pneumologie CHUV
Institution of higher education University of Lausanne - LA
Main discipline Respiratory Diseases
Start/End 01.04.2004 - 30.06.2007
Approved amount 588'214.00
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All Disciplines (2)

Discipline
Respiratory Diseases
Human Ecology

Keywords (6)

cohort; chronic obstructive airway disease (COPD); bronchitis; asthma; atopy; lung function tests

Lay Summary (English)

Lead
Lay summary
The SAPALDIA study (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults) is a multicenter study in eight geographic areas representing the range of environmental, meteorological and sociodemographic conditions of Switzerland. It has allowed to assess prevalence and development of major respiratory and allergic symptoms and diseases, and the age-related decline in lung function. Its aim is to define the association of these health indicators with individual long term exposure to air pollution, other toxic inhalants, life style and molecular factors.When SAPALDIA was initiated in 1991, 9'651 subjects, aged 18 to 60 years, were recruited for a detailed computer-based interview and more than 90% of them underwent lung function and atopy testing. In the 2002 follow-up, 8'047 subjects from the first survey provided health information, 6'528 persons underwent physical re-examination, and 6'345 provided blood samples to establish a blood and DNA bank. The current grant is one of different grants from the Swiss National Foundation that supported the SAPALDIA project. Here are some of the important findings:- Asymptomatic bronchial hyper-responsiveness as assessed by methacholine bronchial challenge in the SAPALDIA population was found to be a predictor for the development of asthma and chronic obstructive pulmonary disease (COPD) on the long term.- Genetic association studies were performed with regard to the development of atopy and asthma. IL-18 is a cytokine that plays an important role in lymphocyte differentiation. It was found that a genetic variant of Il-18 was associated with the prevalence and the development of allergic asthma.- Apart of genetic factors, individual behaviour is of utmost importance. We found that early chronic obstructive pulmonary disease progresses more rapidly in women than in men when they continue to smoke. This finding represents a new contribution to the debate of gender differences in the effect of cigarette smoking.- We also addressed the question of symptoms and lung function in never-smokers upon exposure to environmental tobacco smoke (ETS). Subjects who were exposed to ETS at both surveys were found to have more wheeze, cough and chronic bronchitis, and reported significantly more shortness of breath.- Outdoor air pollution: the effect of living near main streets on respiratory symptoms in adults was studied with the 1991 and 2002 data. It was found that the risk of attacks of breathlessness, of regular phlegm and wheeze were increased for people living near busy motor vehicle traffic.The project with continue with SNF grant 3347CO-108796.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
134276 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) 01.04.2011 Cohort Studies Large

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