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Functional transitions of DNA structure

English title Functional transitions of DNA structure
Applicant Dubochet Jacques
Number 103962
Funding scheme Project funding (Div. I-III)
Research institution Laboratoire d'Analyse Ultrastructurale Centre de Microscopie Electronique Université de Lausanne
Institution of higher education University of Lausanne - LA
Main discipline Molecular Biology
Start/End 01.04.2004 - 31.08.2007
Approved amount 319'925.00
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Keywords (3)

DNA recombination; DNA structure; DNA topology

Lay Summary (English)

Lay summary
DNA molecules change their structure during such vital processes like DNA replication, DNA recombination, DNA repair or DNA transcription. Understanding these functional transitions of DNA structure helps to elucidate molecular mechanisms involved in normal and pathological situations like for example in patients with defective DNA repair. Long term aim of this project is to catalogue various functional DNA structures and to understand the effect of such factors like nucleotide sequence, DNA supercoiling, counterion concentration, mutagens and therapeutic drugs on affecting these functional transitions of DNA structure.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


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Associated projects

Number Title Start Funding scheme
116275 Functional transitions of DNA structure 01.04.2007 Project funding (Div. I-III)