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Dissection of gliding motility and host cell invasion by the apicomplexan parasites

English title Dissection of gliding motility and host cell invasion by the apicomplexan parasites
Applicant Soldati-Favre Dominique
Number 102255
Funding scheme Project funding (Div. I-III)
Research institution Dépt Microbiologie et Médecine Moléculaire Faculté de Médecine Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Biochemistry
Start/End 01.01.2004 - 31.03.2007
Approved amount 497'657.79
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All Disciplines (2)

Discipline
Biochemistry
Cellular Biology, Cytology

Keywords (6)

toxoplasma gondii; plasmodium berghei; invasion; motility; actin; moysin

Lay Summary (English)

Lead
Lay summary
Motion is an intrinsic property of all living organisms and each cell displays a variety of shapes and modes of locomotion. How cytoskeletal structural proteins support cellular movement and how cytoskeletal dynamics and motor proteins are harnessed to generate order and movement are among the fundamental and not fully resolved questions in Biology today. Protozoan parasites belonging to the Apicomplexa are of enormous medical and veterinary significance, being responsible for a wide variety of diseases in human and animals, including malaria, toxoplasmosis, coccidiosis and cryptosporidiosis. Gliding motility is for these obligate intracellular parasites an essential process for for their penetration into host cells their spreading throughout the infected hosts. We propose to study the basic mechanism of parasite locomotion and host cell recognition by Apicomplexa, taking advantage of the easy accessibility of Toxoplasma gondii to genetic manipulation. Apicomplexa move extremely fast, assisted by a machinery composed by a set of distinct molecules that are perfectly synchronised in time and space to function in concert. We propose to determine the composition and the mode of assembly of the complex sustaining this unique mode of gliding motion in Toxoplasma gondii.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

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Associated projects

Number Title Start Funding scheme
116722 Molecular dissection of gliding motility and host cell invasion by the apicomplexa 01.04.2007 Project funding (Div. I-III)

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