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Obesity-Induced Hypertension and Weight Cycling: the Contributory Role of Progressive Vascular Dysfunction

English title Obesity-Induced Hypertension and Weight Cycling: the Contributory Role of Progressive Vascular Dysfunction
Applicant Montani Jean-Pierre
Number 102146
Funding scheme Project funding (Div. I-III)
Research institution Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Clinical Cardiovascular Research
Start/End 01.10.2003 - 30.09.2007
Approved amount 202'938.00
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Keywords (5)

hypertension; obesity; weight cycling; endothelial dysfunction; insulin resistance

Lay Summary (English)

Lead
Lay summary
Obese people are at a higher risk for cardiovascular and renal diseases. They often exhibit a behavior of weight cycling, which may further worsen the health status. Dramatically, the onset of a pattern of weight cycling is shifting towards younger ages, due to the increasing prevalence of overweight in children and adolescents, and the pressure from the media and society for a slim image. Weight cycling during growth may put children, particularly those with preexisting renal dysfunction, at risk for worsening cardiovascular and renal functions, but studies evaluating this relationship are lacking. We hypothesize that weight cycling in younger subjects leads to oscillations in cardiovascular and renal risk factors (blood pressure, heart rate, glomerular filtration rate, blood glucose and lipids) with overshoots above normal values during weight regain periods. The overshoots, when repeated over time, will stress the cardiovascular and renal systems (“repeated overshoot theory”). As a consequence, we postulate that weight cycling, if there is a preexisting renal dysfunction (as it may occur in children born small for gestational age or with obesity-related insulin resistance), will amplify the vulnerability to pathogenic stimuli such as high-salt or high-fat diet. To test that hypothesis, we propose to study in young growing rats (healthy or with preexisting renal dysfunction) whether weight cycling (induced by repeated cycles of controlled food intake) can lead to systemic hypertension, cardiovascular and renal damage, by promoting frequent overshoots of cardiovascular risks factors and whether it can subsequently worsen the hypertension and target-organ damage induced by a high-salt or a high-fat diet. Together, these projects will provide crucial information on the mechanisms by which “weight (food) cycling” during growth leads to cardiovascular and renal disorders, particularly if there is preexisting renal dysfunction. This area has special clinical relevance since the onset of a pattern of weight cycling is shifting towards younger ages.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
118041 Weight cycling during growth: A risk factor for cardiovascular and renal diseases 01.10.2007 Project funding (Div. I-III)
61634 Mechanisms of obesity-induced hypertension. 01.10.2000 Project funding (Div. I-III)

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