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Molekulare Grundlagen immupathologischer Herz-Kreislauferkrankungen: A: Identifikation neuer kardiovaskulärer Autoantigene B: Die Rolle vaskulärer Endothelzellen in Herz- und Lebertransplantation

English title Molecular basis of cardiovascular immunopathological disease: A: Identification of new cardiovascular autoantigens B: Role of vascular endothelial cells in heart- and liver transplantation
Applicant Ludewig Burkhard
Number 102103
Funding scheme Project funding (Div. I-III)
Research institution Laborforschungsabteilung Kantonsspital St. Gallen
Institution of higher education Cantonal hospital of St.Gallen - KSPSG
Main discipline Clinical Immunology and Immunopathology
Start/End 01.04.2004 - 31.03.2007
Approved amount 176'118.00
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All Disciplines (2)

Discipline
Clinical Immunology and Immunopathology
Immunology, Immunopathology

Keywords (6)

AUTOIMMUNITY; IMMUNOPATHOLOGY; MYOCARDITIS; ARTERITIS; ATHEROSCLEROSIS; TRANSPLANTATION

Lay Summary (English)

Lead
Lay summary
Interactions of immune cells with cells from the cardiovascular system are critical in a number of diseases of the heart and the vasculature. This project has two major aims: (A) To identify and characterize antigens involved in cardiovascular immunopathological disease and (B) to investigate the role of non-hematopoietic allograft cells and particularly of vascular endothelial cells (EC) in vivo in the course of solid organ transplantation. Several transgenic mouse models will be employed to better understand the processes and mechanisms involved in immunopathological cardiovascular disease. We expect to deliver a detailed characterization of selected candidate autoantigens that may help to delineate their pathogenic potential in the chronological processes of cardiovascular diseases and may lead to the development of new immunotherapeutical treatment strategies. Furthermore, it is anticipated that our studies will improve insight into the immunological mechanisms mediating allograft recognition and rejection.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
63415 Identification of heart- and artery-specific auto-antigens and their pathogenic role in cardiovascular inflammatory diseases 01.04.2001 Project funding (Div. I-III)
116499 Role of professional and non-professional antigen presenting cells in cardiovascular immunopathological disease 01.04.2007 Project funding (Div. I-III)

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