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Dissection of human memory T lymphocytes

English title Dissection of human memory T lymphocytes
Applicant Sallusto Federica
Number 101962
Funding scheme Project funding (Div. I-III)
Research institution Istituto di Ricerca in Biomedicina (IRB)
Institution of higher education Università della Svizzera italiana - USI
Main discipline Immunology, Immunopathology
Start/End 01.10.2003 - 30.09.2006
Approved amount 337'038.00
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Keywords (6)

Human; Memory; T lymphocyte; TH1 TH2 CTL; Chemokine receptor; Cytokine gene

Lay Summary (English)

Lead
Lay summary
The aim of our project was to understand how naive T lymphocytes are stimulated in vivo and in vitro and how they differentiate into effector and memory T cells of different types that mediate protection against intracellular and extracellular pathogens but can also cause pathologies such as autoimmunity and allergy. In particular we performed global gene analysis of human CD4+ effector and memory T cells (including subsets defined as central memory, effector memory and follicular helper). We described surface markers to identify in humans IL-17 producing inflammatory T cells (Th17 cells) and IL-10 producing autoreactive T cells. We also addressed using a mouse experimental system the impact of the kinetics of antigen-presentation to T cell fate determination and generation of memory T cells and analyzed the migratory pathways of CD8+ central and effector memory T cells in different tissues under steady state conditions and during inflammatory responses.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Associated projects

Number Title Start Funding scheme
116440 Memory T cell subsets in man and mouse: identification, characterization and function 01.07.2007 Project funding (Div. I-III)

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