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HIV accessory proteins and the biology of the cell

English title HIV accessory proteins and the biology of the cell
Applicant Trono Didier
Number 100886
Funding scheme Project funding (Div. I-III)
Research institution Dépt Microbiologie et Médecine Moléculaire Faculté de Médecine Université de Genève
Institution of higher education EPF Lausanne - EPFL
Main discipline Molecular Biology
Start/End 01.04.2003 - 31.03.2008
Approved amount 1'336'000.00
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Keywords (5)

HIV; NEF; Trafficking; T lymphocytes; Signal transduction

Lay Summary (English)

Lay summary
Viral replication requires not only that the virus subvert cellular pathways, but also that it overcome intracellular lines of defense. The Vif gene of lentiviruses counters APOBEC proteins, a subgroup of polynucleotide cytidine deaminases also active on hepatitis B virus and some endogenous retroelements. Our effort for the next couple of years will revolve around a few of the questions raised by the discovery of antiviral cytidine deaminases, with an eye both on the basic biology of this form of intrinsic immunity and on the therapeutic opportunities if might open. We will thus pursue the following specific aims:
1. Fufther explore cytidine deamination as a barrier against chronic HBV infection.
2. Investigating the biochemistry of APOBEC-mediated antiretroviral action.
3. Searching for inhibitors of Vif action.
4.Probing the role of cytidine deaminases in the control of genome evolution.
We are confident that this work will shed new light on the fragile equilibrium between humans and the realm of retroelements, whether exogenous or endogenous.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants


Associated projects

Number Title Start Funding scheme
120035 Innate defenses against retroelements 01.04.2008 Project funding (Div. I-III)
50560 HIV nef and the biology of the cell 01.10.1997 Project funding (Div. I-III)